Dynein Intermediate chain antibody [70.1]

Catalogue Number: GTX26304-GTX

Manufacturer:GeneTex
Preservative:15 mM Sodium azide
Physical state:Liquid
Type:Monoclonal Primary Antibody - Unconjugated
Alias:dynein axonemal intermediate chain 1
Shipping Condition:Blue Ice
Unit(s): 100 ul
Host name: Mouse
Clone: 70.1
Isotype: IgM
Immunogen: cytoplasmic dynein from chicken embryo brain
Application: ELISA, ICC, IF, IP, EM, WB

Description

Description: Eukaryotic cells rely on actin and microtubule-based protein ""motors"" to generate intracellular movements (4). These protein ""motors"" contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kD), three intermediate chains (70-125 kD), and at least four light chains (15-25 kD) (5).

Additional Text

Gene Name

DNAI1

Gene ID

431654

Purification

Unpurified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500~1:2,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.