Collagen I antibody [COL-1]
Catalogue Number: GTX26308-GTX
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IHC-Fr analysis of pig tongue tissue using GTX26308 Collagen I antibody [COL-1] at 1:4,000.
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IHC-Fr analysis of human tongue tissue using GTX26308 Collagen I antibody [COL-1] at 1:2,000.
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Collagen I antibody [COL-1] detects Collagen I protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded rabbit tongue. Collagen I stained by Collagen I antibody [COL-1] (GTX26308) diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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The data was published in the journal Biomed Res Int in 2015. PMID: 25918720
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The data was published in the journal J Orthop Surg Res in 2019.PMID: 31272458
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The data was published in the journal Int J Mol Sci in 2020. PMID: 32235811
| Manufacturer: | GeneTex |
| Preservative: | 15 mM Sodium azide |
| Molecular Weight: | 139 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | collagen type I alpha 1 chain |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | COL-1 |
| Isotype: | IgG1 |
| Immunogen: | bovine skin collagen type I |
| Application: | ELISA, ICC, IF, IHC-P, IP, WB, IHC-Fr, DB, IHC |
Description
Description: Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
Additional Text
Gene Name
COL1A1
Molecular Weight
139
Gene ID
282187
Purification
Unpurified
Uniprot ID
P02453
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
IHC-Fr: 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
Collagen I antibody (Collagen 1 antibody) detects type I collagen, a fibrillar type collagen found in almost all connective tissues. The main isoform of type I collagen is a heterotrimer of two α1 and one α2 chains subject to significant posttranslational modification and crosslinking. Mutations in type I collagen are found in osteogenesis imperfecta and Ehlers-Danlos syndrome, but this collagen is also linked to other connective tissue disease as well as disorders associated with aging.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX26308 Datasheet
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