TNF Receptor II antibody [HM102]
Catalogue Number: GTX27369-GTX
| Manufacturer: | GeneTex |
| Preservative: | no preservative|No preservative |
| Molecular Weight: | 48 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CD120b,TBPII,TNF receptor superfamily member 1B,TNFBR,TNFR1B,TNFR2,TNFR75,TNFR80,TNFRII,TNFRSF1B,p75,p75TNFR,TNF receptor II |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 50 ug |
| Host name: | Rat |
| Clone: | HM102 |
| Isotype: | IgG2a |
| Immunogen: | The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF Receptor II as well as the soluble form of TNF Receptor II which is generated by proteolytic cleavage of the extracellular domain. |
| Application: | ELISA, FC, IP, WB, IHC-Fr, Act |
Description
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Additional Text
Uniprot ID
P20333
Gene Name
TNFRSF1B
Gene ID
7133
Purification
Protein G purified
Concentration
100 ug/ml
Molecular Weight
48
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C.
Application Notes
FCM: 10µg/ml antibody in PBS/1% serum / 10⁵ microglia cells. Activation: 2µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX27369 Datasheet
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