TCR alpha + TCR beta antibody [R73] (FITC)

Catalogue Number: GTX29317-GTX

Manufacturer:GeneTex
Preservative:0.02% Sodium azide|0.02% Sodium azide
Physical state:Liquid
Type:Monoclonal Primary Antibody - Conjugated
Alias:RATTCBC1 , MGC109620 , TCR alpha + beta , TCB , RATTCB , Tcrb , TCBC1 , 24820
Shipping Condition:Blue Ice
Unit(s): 50 ug
Host name: Mouse
Clone: R73
Isotype: IgG1
Immunogen: Rat T Blasts
Application: FC, IHC-Fr

Description

Description: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Additional Text

Gene Name

TCRB

Concentration

0.1 mg/ml

Purification

Protein G purified

Gene ID

24820

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

For FACS: Use at an assay dependent dilution. For IHC-Fr: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles. Protect from light.