Caspase 8 blocking peptide

Catalogue Number: GTX31285-PEP-GTX

Manufacturer:	GeneTex
Preservative:	0.02% Sodium azide\|0.02% Sodium azide
Physical state:	Liquid
Type:	Blocking Peptides
Alias:	Caspase 8 , Alps2B , Cap4 , Casp-8 , Flice , Mach , Mch5 , Casp8
Shipping Condition:	Dry Ice
Unit(s):	50 ug
Application:	NT, Inh

Overview
Datasheets

Description

Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

CASP8

Gene ID

841

Concentration

200 ug/ml

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Short Description

Caspase 8 peptide is used for blocking the activity of Caspase 8 antibody (catalog number GTX31285).

Storage Note

Store as concentrated solution. Aliquot and store at -20C or below. Avoid freeze-thaw cycles.

GTX31285-PEP Datasheet

Price

£145.00

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Quantity
Unit Size

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