sRANKL blocking peptide

Catalogue Number: GTX31300-PEP-GTX

Manufacturer:	GeneTex
Preservative:	0.02% Sodium azide\|0.02% Sodium azide
Physical state:	Liquid
Type:	Blocking Peptides
Alias:	Tnf Superfamily Member 11 , Cd254 , Odf , Opgl , Optb2 , Rankl , Tnlg6B , Trance , Hrankl2 , Sodf , Tnfsf11
Shipping Condition:	Dry Ice
Unit(s):	50 ug
Application:	NT, Inh

Overview
Datasheets

Description

Description: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced tra

Additional Text

Gene ID

8600

Gene Name

TNFSF11

Concentration

200 ug/ml

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Short Description

sRANKL peptide is used for blocking the activity of sRANKL antibody (catalog number GTX31300).

Storage Note

Store as concentrated solution. Aliquot and store at -20C or below. Avoid freeze-thaw cycles.

GTX31300-PEP Datasheet

Price

£145.00

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