B-Raf (V600E Mutant Specific) antibody [RM8]

Catalogue Number: GTX33595-GTX

Manufacturer:	GeneTex
Preservative:	0.09% Sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	BRAF,BRAF1,BRaf protooncogene, serine/threonine kinase,Braf,NS7,RAFB1,B-Raf,B-Raf proto-oncogene, serine/threonine kinase
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rabbit
Clone:	RM8
Isotype:	IgG
Immunogen:	A peptide corresponding to BRAF V600E mutant
Application:	ELISA, ICC, IF, IHC-P, WB

Overview
Datasheets

Description

Description: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Additional Text

Gene Name

BRAF

Uniprot ID

P15056

Gene ID

673

Molecular Weight

Purification

Protein A purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 0.5 - 2 µg/mL. ICC/IF: 0.5 - 5 µg/mL. IHC-P: 0.5 - 5 µg/mL. ELISA: 0.5 - 2 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX33595 Datasheet

GTX33595 Reference

Price

£589.00

-

Quantity
Unit Size

Find out about delivery