CFTR antibody [CFTR/1643]

Catalogue Number: GTX34589-GTX

Manufacturer:	GeneTex
Preservative:	0.05% Sodium azide\|0.05% Sodium azide
Molecular Weight:	168
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	ABC35 , ABCC7 , CF , CFTR , CFTR/MRP , MRP7 , TNRCFTR , cystic fibrosis transmembrane conductance regulator , dJ760C5.1 , CF transmembrane conductance regulator
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	CFTR/1643
Isotype:	IgG2b
Immunogen:	Recombinant fragment (around aa 258-385) of human CFTR protein (exact sequence is proprietary)
Application:	FC, IHC-P, PA

Overview
Datasheets

Description

Description: This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]

Additional Text

Gene Name

CFTR

Uniprot ID

P13569

Gene ID

1080

Purification

Protein A/G Purified

Concentration

0.2 mg/ml

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Application Notes

IHC-P: 1-2µg/ml for 30 minutes at RT. FCM: 1-2µg/10⁶ cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX34589 Datasheet

Price

£504.00

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Quantity
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