E-Cadherin antibody [CDH1/1525]

Catalogue Number: GTX34680-GTX

Manufacturer:	GeneTex
Preservative:	0.05% Sodium azide\|0.05% Sodium azide
Molecular Weight:	97
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Arc1 , CD324 , CDH1 , CDHE , ECAD , LCAM , UVO , cadherin 1 , E-Cadherin , Cadherin 1
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	CDH1/1525
Isotype:	IgG1
Immunogen:	Recombinant human E-Cadherin protein
Application:	ICC, IF, IHC-P, WB, PA

Overview
Datasheets

Description

Description: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Additional Text

Gene Name

CDH1

Gene ID

999

Uniprot ID

P12830

Purification

Protein A/G Purified

Concentration

0.2 mg/ml

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Application Notes

WB: 1-2µg/ml. ICC/IF: 1-2µg/ml. IHC-P: 1-2µg/ml for 30 minutes at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX34680 Datasheet

Price

£504.00

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Quantity
Unit Size

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