Factor XIIIa antibody [F13A1/1448]
Catalogue Number: GTX34714-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Molecular Weight: | 83 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | F13A , F13A1 , coagulation factor XIII A chain , Factor XIIIa , Factor XIII A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | F13A1/1448 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant fragment of human Factor XIIIa protein (aa46-181) (exact sequence is proprietary) |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, PA |
Description
Description: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Additional Text
Gene ID
2162
Gene Name
F13A1
Uniprot ID
P00488
Purification
Protein A/G Purified
Concentration
0.2 mg/ml
Molecular Weight
83
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Application Notes
WB: 1-2µg/ml. ICC/IF: 1-2µg/ml. IHC-P: 1-2µg/ml for 30 min at RT. FCM: 1-2µg/10⁶ cells. ELISA: 2-4µg/ml (for coating). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX34714 Datasheet
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