Topoisomerase II alpha antibody [TOP2A/1361]

Catalogue Number: GTX35137-GTX

Manufacturer:	GeneTex
Preservative:	0.05% Sodium azide\|0.05% Sodium azide
Molecular Weight:	174
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	TOP2 , TOP2A , TP2A , topoisomerase (DNA) II alpha , Topoisomerase II alpha , Topo II alpha , DNA topoisomerase II alpha
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	TOP2A/1361
Isotype:	IgG2b
Immunogen:	Recombinant human Topoisomerase II alpha fragment (aa1352-1493)
Application:	ICC, IF, IHC-P, WB, PA

Overview
Datasheets

Description

Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Additional Text

Gene Name

TOP2A

Gene ID

7153

Uniprot ID

P11388

Purification

Protein A/G Purified

Concentration

0.2 mg/ml

Molecular Weight

174

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1-2µg/ml. ICC/IF: 1-2µg/ml. IHC-P: 1-2µg/ml for 30 min at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX35137 Datasheet

GTX35137 Reference

Price

£504.00

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