Catalogue Number: GTX36254-GTX
Manufacturer: | GeneTex |
Preservative: | 0.05% Sodium azide |
Physical state: | Liquid |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | CAMK , CAMK-II , CAMKG |
Shipping Condition: | Blue Ice |
Unit(s): | 50 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | CaMKII synthetic peptide with oxidized Met281/282 |
Application: | ICC, IF, IHC-P, WB, IHC-Fr, PLA |
Description: Calcium/calmodulin-dependent protein kinase II (CaMKII) couples increases in Ca2+ to fundamental responses in excitable cells including activation of ion channels, gene transcription and apoptosis. CaMKII is activated by angiotensin II-induced oxidation, which leads to apoptosis in cardiomyocytes. CaMKII activity is also enhanced by pro-oxidant conditions, and the oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM.
Polyclonal
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
For WB, use at a dilution of 1:1,000, For IF, use at a dilution of 1:50 with paraffin-embedded sections and 1:100 with frozen sections.