Neutrophil elastase antibody [39A]

Catalogue Number: GTX41327-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Molecular Weight:	29
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	elastase, neutrophil expressed , ELA2 , GE , HLE , HNE , NE , PMN-E , SCN1
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Mouse
Clone:	39A
Isotype:	IgG1
Immunogen:	Elastase from human neutrophils
Application:	ELISA, FC, FA

Overview
Datasheets

Description

Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

Additional Text

Uniprot ID

P08246

Gene ID

1991

Concentration

0.5 mg/ml

Gene Name

ELANE

Purification

Protein G purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX41327 Datasheet

Price

£475.00

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