FBXO11 antibody, Internal
Catalogue Number: GTX46904-GTX
GTX46904 Image
GTX46904 Image
GTX46904 Image
GTX46904 Image
ChIP analysis of HCT116 cells using GTX46904 FBXO11 antibody. Use 0.5µg antibody GTX46904 FBXO11 antibody for ChIP assay. Quiescent human colon carcinoma HCT116 cultures were treated with 10% FBS for three time points (0, 15, 30min) or (0, 30, 60min) were used in Matrix-ChIP and real-time PCR assays at EGR1 gene (Exon1) and 15kb upstream site. (+) : Add blocking peptide (-) : no blocking peptide
GTX46904 Image
WB analysis of 293T cells using GTX46904 FBXO11 antibody at 0.2-1µg/ml.
GTX46904 Image
WB analysis of human ovary tumor tissue using GTX46904 FBXO11 antibody at 1µg/ml.
| Manufacturer: | GeneTex |
| Preservative: | 0.09% sodium azide |
| Molecular Weight: | 104 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | F-box protein 11 , FBX11 , IDDFBA , PRMT9 , UBR6 , UG063H01 , VIT1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide corresponding to an Internal region of Human FBXO11 |
| Application: | ChIP, WB |
Description
Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Additional Text
Gene Name
FBXO11
Uniprot ID
Q86XK2
Gene ID
80204
Concentration
0.5-1 mg/ml
Purification
Affinity Purified
Molecular Weight
104
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Application Notes
WB: 0.2-2.5 µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX46904 Datasheet
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