Human Follistatin protein (active)
Catalogue Number: GTX48321-PRO-GTX
| Manufacturer: | GeneTex |
| Physical state: | Lyophilized |
| Type: | Glycoproteins |
| Alias: | follistatin , FS |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug |
| Application: | FA |
Description
Description: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Additional Text
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED₅₀ is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.
Short Description
Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.
Storage Note
Store at -20C or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
GTX48321-PRO Datasheet
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