Human IL5 protein (active)
Catalogue Number: GTX48426-PRO-GTX
| Manufacturer: | GeneTex |
| Physical state: | Lyophilized |
| Type: | Interleukins |
| Alias: | interleukin 5 , EDF , IL-5 , TRF |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 ug |
| Application: | FA |
Description
Description: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Additional Text
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
The ED₅₀ was determined by the dose-dependent proliferation of TF-1 cells was < 0.15 ng/ml, corresponding to a specific activity of > 6.6 x 10⁶ units/mg.
Short Description
Recombinant human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
Storage Note
Store at -20C or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
GTX48426-PRO Datasheet
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