Human IL4 protein (active)
Catalogue Number: GTX48427-PRO-GTX
| Manufacturer: | GeneTex |
| Physical state: | Lyophilized |
| Type: | Interleukins |
| Alias: | interleukin 4 , BCGF-1 , BCGF1 , BSF-1 , BSF1 , IL-4 |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 ug |
| Application: | FA |
Description
Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Additional Text
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
The ED₅₀ was determined by the dose-dependent stimulation of human TF-1 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 10⁶ units/mg.
Short Description
Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
Storage Note
Store at -20C or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
GTX48427-PRO Datasheet
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