Bmi1 antibody

Catalogue Number: GTX48576-GTX

Manufacturer:GeneTex
Preservative:0.05% Sodium azide
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:BMI1 proto-oncogene, polycomb ring finger , FLVI2/BMI1 , PCGF4 , RNF51 , flvi-2/bmi-1
Shipping Condition:Blue Ice
Unit(s): 50 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: A synthetic peptide made to an internal region (within residues 1-100) of human Bmi1. [Swiss-Prot# P35226]
Application: ICC, IF, WB

Description

Description: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Additional Text

Uniprot ID

P35226

Concentration

1 mg/ml

Gene ID

100532731; 648

Purification

Affinity Purified

Molecular Weight

37

Gene Name

BMI1, COMMD3-BMI1

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 2 µg/ml. ICC/IF: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.