PDCD4 (phospho Ser457) antibody [2E10.C12]

Catalogue Number: GTX48644-GTX

Manufacturer:	GeneTex
Preservative:	0.01% Sodium azide
Molecular Weight:	52
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	programmed cell death 4 , H731
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	9G6
Isotype:	IgG1
Immunogen:	Synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.
Application:	ELISA, WB, IHC, Multiplex

Overview
Datasheets

Description

Description: Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.

Additional Text

Gene Name

PDCD4

Uniprot ID

Q53EL6

Gene ID

27250

Modification

Phosphorylated, Ser457

Molecular Weight

Purification

Protein A purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Concentration

1 mg/ml

Application Notes

WB: 1:1000-1:3000. ELISA: 1:400000. IHC: 1.25-2.5 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX48644 Datasheet

Price

£410.00

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