IL7 Receptor alpha antibody
Catalogue Number: GTX48715-GTX
GTX48715 Image
GTX48715 Image
GTX48715 Image
ELISA analysis of BSA-conjugated immunizing peptide using serially diluted GTX48715 IL7 Receptor alpha antibody. Coating : 0.1 µg
GTX48715 Image
WB analysis of various samples using GTX48715 IL7 Receptor alpha antibody. Lane 1 : Protein ladder Lane 2 : Human spleen tissue lysate Lane 3 : U251 whole cell lysate Lane 4 : Human pancreas tissue lysate Lane 5 : Molt-4 whole cell lysate Dilution : 1 µg/mL
| Manufacturer: | GeneTex |
| Preservative: | 0.01% Sodium azide |
| Molecular Weight: | 52 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | interleukin 7 receptor , CD127 , IL-7Ralpha |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to a region near the carboxy terminus of mouse IL-7 receptor protein. |
| Application: | ELISA, WB, DB, IHC |
Description
Description: Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.
Additional Text
Gene Name
IL7R
Concentration
1.2 mg/mL
Uniprot ID
P16872
Purification
Affinity Purified
Gene ID
16197
Molecular Weight
52
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:1000-1:10000. ELISA: 1:5000-1:50000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX48715 Datasheet
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