IMPA1 antibody
Catalogue Number: GTX54348-GTX
GTX54348 Image
GTX54348 Image
GTX54348 Image
GTX54348 Image
GTX54348 Image
GTX54348 Image
WB analysis of various sample lysates using GTX54348 IMPA1 antibody. Dilution : 1:1000 Loading : 25µg per lane
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ICC/IF analysis of A549 cells using GTX54348 IMPA1 antibody. Blue : DAPI
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IHC-P analysis of human colon tissue using GTX54348 IMPA1 antibody. Dilution : 1:100
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IHC-P analysis of mouse testis tissue using GTX54348 IMPA1 antibody. Dilution : 1:100
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IHC-P analysis of rat kidney tissue using GTX54348 IMPA1 antibody. Dilution : 1:100
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 30 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | inositol monophosphatase 1 , IMP , IMPA , MRT59 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1). |
| Application: | ICC, IF, IHC-P, WB |
Description
Description: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Additional Text
Gene Name
IMPA1
Uniprot ID
P29218
Purification
Affinity Purified
Gene ID
3612
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
30
Application Notes
WB: 1:500 - 1:2000. ICC/IF: 1:10 - 1:100. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX54348 Datasheet
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