MCM6 antibody
Catalogue Number: GTX54353-GTX
GTX54353 Image
GTX54353 Image
GTX54353 Image
GTX54353 Image
GTX54353 Image
IP analysis of HeLa cell lysate using GTX54353 MCM6 antibody. Antibody amount : 3µg / 300µg lysate Dilution : 1:1000
GTX54353 Image
WB analysis of various sample lysates using GTX54353 MCM6 antibody. Dilution : 1:1000 Loading : 25µg per lane
GTX54353 Image
ICC/IF analysis of U2OS cells using GTX54353 MCM6 antibody.
GTX54353 Image
IHC-P analysis of human lung cancer tissue using GTX54353 MCM6 antibody. Dilution : 1:100
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide|0.02% Sodium azide |
| Molecular Weight: | 93 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | minichromosome maintenance complex component 6 , MCG40308 , Mis5 , P105MCM |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 562-821 of human MCM6 (NP_005906.2). |
| Application: | ICC, IF, IHC-P, IP, WB |
Description
Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Additional Text
Gene Name
MCM6
Uniprot ID
Q14566
Gene ID
4175
Purification
Affinity Purified
Molecular Weight
93
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500 - 1:2000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. IP: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX54353 Datasheet
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