Pyruvate Carboxylase antibody

Catalogue Number: GTX54577-GTX

Manufacturer:	GeneTex
Preservative:	0.02% Sodium azide\|0.02% Sodium azide
Molecular Weight:	130
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	pyruvate carboxylase , PCB
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 879-1178 of human PC (NP_001035806.1).
Application:	ICC, IF, IP, WB

Overview
Datasheets

Description

Description: This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Additional Text

Gene ID

5091

Gene Name

Uniprot ID

P11498

Purification

Affinity Purified

Molecular Weight

130

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500 - 1:2000. ICC/IF: 1:10 - 1:100. IP: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX54577 Datasheet

Price

£386.00

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