Nav1.2 antibody
Catalogue Number: GTX54797-GTX
GTX54797 Image
GTX54797 Image
GTX54797 Image
GTX54797 Image
IHC-Fr analysis of mouse hippocampus tissue using GTX54797 Nav1.2 antibody. Panel A : NaV1.2 (red) is present in dendrites of pyramidal neurons in the CA3 region. Panel B : Staining of?interneurons in the pyramidal layer with mouse anti-Parvalbumin (green) demonstrates the restriction of NaV1.2 to dendrites (arrows) extending from the pyramidal layer (P). Panel C : Confocal merge of panels A and B.
GTX54797 Image
IP analysis of rat brain tissue lysate using GTX54797 Nav1.2 antibody. The lower arrow indicates the IgG heavy chain.WB was performed with the GTX54797 antibody. IP reaction : 6 µg Lane 1 : Rat brain lysates Lane 2 : Lysates immunoprecipitated with?Anti-SCN2A (NaV1.2)?Antibody Lane 3 : Lysates immunoprecipitated with pre-immune rabbit serum
GTX54797 Image
WB analysis of rat brain membrane lysate using GTX54797 Nav1.2 antibody preincubated with or without immunogen peptide. Dilution : 1:200
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Molecular Weight: | 228 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | sodium voltage-gated channel alpha subunit 2 , NachII , Nav1.2 , RII/RIIA , RNSCPIIR , SCN , Scn2a1 , Scn2a2 , ScpII |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide (C)ASAESRDFSGAGGIGVFSE, corresponding to amino acid residues 467-485 (Intracellular loop between domains I and II) of rat NaV1.2 (Accession : P04775). |
| Application: | ICC, IF, IP, WB, IHC-Fr |
Description
Description: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]
Additional Text
Gene Name
SCN2A
Concentration
0.8 mg/ml
Uniprot ID
P04775
Purification
Affinity Purified
Molecular Weight
228
Gene ID
24766
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX54797 Datasheet
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