Neurexin 1 antibody
Catalogue Number: GTX54845-GTX
GTX54845 Image
GTX54845 Image
GTX54845 Image
WB analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates using GTX54845 Neurexin 1 antibody preincubated with or without immunogen peptide. Dilution : 1:400
GTX54845 Image
Live cell imaging analysis of intact living PC12 cells using GTX54845 Neurexin 1 antibody. Panel A : Primary antibody Panel B : Live view of the cell Dilution : 1:50
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Molecular Weight: | 168 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | neurexin 1 , Nrxn1b |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 (Extracellular, N-terminus) of rat Neurexin 1α (Accession : Q63372). |
| Application: | ICC, IF, WB, IHC-Fr, LCImg |
Description
Description: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]
Additional Text
Gene Name
NRXN1
Concentration
0.8 mg/ml
Uniprot ID
Q63372
Purification
Affinity Purified
Molecular Weight
168
Gene ID
60391
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX54845 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations