CD11b antibody [M1/70] (APC)

Catalogue Number: GTX57222-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	integrin alpha M , CD11b/CD18 , CR3 , CR3A , Cd11b , F730045J24Rik , Ly-40 , MAC1 , Mac-1 , Mac-1a
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rat
Clone:	M1/70
Isotype:	IgG2b
Immunogen:	B10 mouse spleen cells enriched for T cells
Application:	FC

Overview
Datasheets

Additional Text

Gene Name

ITGAM

Concentration

0.2 mg/ml

Purification

Affinity Purified

Gene ID

16409

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Short Description

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

GTX57222 Datasheet

GTX57222 Reference

Price

£273.00

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