Estrogen Receptor alpha antibody [GT9004]
Catalogue Number: GTX60340-GTX
GTX60340 Image
GTX60340 Image
ChIP analysis of sheared chromatin from MCF7 cells treated for 1 hour with estradiol using GTX60340 Estrogen Receptor alpha antibody [GT9004]. The IP'd DNA was analysed with an Illumina Genome Analyzer. Library preparation, cluster generation and sequencing were performed according to the manufacturer's instructions. The 36 bp tags were aligned to the human genome using the ELAND algorithm. This figure shows the obtained peaks near the TFF1 gene on chromosome 21 (figure 1A), the GREB1 and HAAO genes on chromosome 2 (figure 1B and C), and the ZNF185 gene on the X-chromosome (figure 1D).
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide|0.05% Sodium azide |
| Molecular Weight: | 66 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ul |
| Host name: | Mouse |
| Clone: | GT9004 |
| Isotype: | IgG1 |
| Immunogen: | Human ER alpha (estrogen receptor alpha), using a synthetic peptide. |
| Application: | ELISA, IP, ChIP, WB, EMSA |
Description
Description: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Additional Text
Gene ID
2099
Gene Name
ESR1
Molecular Weight
66
Uniprot ID
P03372
Purification
Unpurified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX60340 Datasheet
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