Glucocorticoid Receptor antibody [6E6]

Catalogue Number: GTX60389-GTX

Manufacturer:	GeneTex
Preservative:	0.03% Sodium azide
Molecular Weight:	86
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	nuclear receptor subfamily 3 group C member 1 , GCCR , GCR , GCRST , GR , GRL
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	6E6
Isotype:	IgG1
Immunogen:	Purified recombinant fragment of human NR3C1 expressed in E. Coli.
Application:	ELISA, FC, ICC, IF, IHC-P, WB

Overview
Datasheets

Description

Description: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Additional Text

Gene ID

2908

Gene Name

NR3C1

Uniprot ID

P04150

Molecular Weight

Purification

Unpurified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Application Notes

WB: 1/500 - 1/2000. ICC/IF: 1/200 - 1/1000. IHC-P: 1/200 - 1/1000. FCM: 1/200 - 1/400. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX60389 Datasheet

Price

£410.00

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Quantity
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