Apolipoprotein B antibody [6G6]

Catalogue Number: GTX60445-GTX

Manufacturer:	GeneTex
Preservative:	0.03% Sodium azide
Molecular Weight:	516
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	apolipoprotein B , FLDB , LDLCQ4 , apoB-100 , apoB-48
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	6G6
Isotype:	IgG1
Immunogen:	Purified recombinant fragment of human ApoB (AA: 3900 - 4110)expressed in E. Coli.
Application:	ELISA, FC, ICC, IF, WB

Overview
Datasheets

Description

Description: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

APOB

Uniprot ID

P04114

Gene ID

338

Molecular Weight

516

Purification

Unpurified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Application Notes

WB: 1/500 - 1/2000. ICC/IF: 1/200 - 1/1000. FCM: 1/200 - 1/400. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX60445 Datasheet

GTX60445 Reference

Price

£410.00

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