p21 Cip1 antibody [GT1032]

Catalogue Number: GTX629543-GTX

Molecular Weight:18
Physical state:Liquid
Type:Monoclonal Primary Antibody - Unconjugated
Alias:cyclin dependent kinase inhibitor 1A , CAP20 , CDKN1 , CIP1 , MDA-6 , P21 , SDI1 , WAF1 , p21CIP1
Shipping Condition:Dry Ice
Unit(s): 100 ul, 25 ul, 10 ul
Host name: Mouse
Clone: GT1032
Isotype: IgG2a
Immunogen: Recombinant protein encompassing a sequence within the center region of human p21 Cip1. The exact sequence is proprietary.
Application: ICC, IF, IP, WB


Description: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]

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1.45 mg/ml

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