p21 Cip1 antibody [GT1032]

Catalogue Number: GTX629543-GTX

Manufacturer:	GeneTex
Preservative:	No Preservative
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	cyclin dependent kinase inhibitor 1A , CAP20 , CDKN1 , CIP1 , MDA-6 , P21 , SDI1 , WAF1 , p21CIP1
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Mouse
Clone:	GT1032
Isotype:	IgG2a
Immunogen:	Recombinant protein encompassing a sequence within the center region of human p21 Cip1. The exact sequence is proprietary.
Application:	FACS, ICC, IF, IHC-P, IP, WB

Overview
Datasheets

Description

Description: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]

Additional Text

Gene ID

1026

Gene Name

CDKN1A

Uniprot ID

P38936

Concentration

1.45 mg/ml

Purification

Protein A purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Short Description

p21 (Cip1) antibody recognizes p21Cip1 protein, a cyclin-dependent kinase inhibitor with a predicted molecular weight of 18 kDa. p21 is a major downstream regulator of p53 activity in response to DNA damage to control cell cycle arrest. p21 also interacts with proliferating cell nuclear antigen (PCNA) to inhibit PCNA-dependent S-phase DNA synthesis.

GTX629543 Datasheet

GTX629543 Reference

Price

£285.00

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Quantity
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