ROCK1 + ROCK2 antibody [GT261]
Catalogue Number: GTX629971-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Rho associated coiled-coil containing protein kinase 1 , P160ROCK , ROCK-I |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Mouse |
| Clone: | GT261 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein encompassing a sequence within the N-terminus region of human ROCK1. The exact sequence is proprietary. |
| Application: | WB |
Description
Description: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]
Additional Text
Concentration
1 mg/ml
Gene Name
ROCK1
Gene ID
6093
Uniprot ID
Q13464
Purification
Protein G purified
Molecular Weight
158
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX629971 Datasheet
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