JNK (phospho Thr183/Tyr185) antibody [HL1008]

Catalogue Number: GTX635799-GTX

Manufacturer:GeneTex
Molecular Weight:48
Physical state:Liquid
Type:Monoclonal Primary Antibody - Unconjugated
Alias:mitogen-activated protein kinase 8 , JNK , JNK-46 , JNK1 , JNK1A2 , JNK21B1/2 , PRKM8 , SAPK1 , SAPK1c
Shipping Condition:Blue Ice
Unit(s): 100 ul, 25 ul, 10 ul
Host name: Rabbit
Clone: HL1008
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human JNK (phospho Thr183/Tyr185). The exact sequence is proprietary.
Application: WB

Description

Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Additional Text

Uniprot ID

P45983

Concentration

1 mg/ml

Gene ID

5599

Modification

Phosphorylated, Thr183

Molecular Weight

48

Gene Name

MAPK8

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Gene Alias

mitogen-activated protein kinase 8 , JNK , JNK-46 , JNK1 , JNK1A2 , JNK21B1/2 , PRKM8 , SAPK1 , SAPK1c

Price
300.00


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