JNK (phospho Thr183/Tyr185) antibody [HL1008]
Catalogue Number: GTX635799-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | Recombinant Monoclonal |
| Alias: | mitogen-activated protein kinase 8 , JNK , JNK-46 , JNK1 , JNK1A2 , JNK21B1/2 , PRKM8 , SAPK1 , SAPK1c |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | HL1008 |
| Isotype: | IgG |
| Immunogen: | Carrier-protein conjugated synthetic peptide surrounding phospho Thr183/Tyr185 of human JNK. The exact sequence is proprietary. |
| Application: | IHC-P, WB |
Description
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Additional Text
Uniprot ID
P45983
Concentration
1 mg/ml
Gene ID
5599
Modification
Phosphorylated, Thr183
Molecular Weight
48
Purification
Protein A purified
Gene Name
MAPK8
Antibody Clonality
Recombinant Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX635799 Datasheet
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