Myelin basic Protein antibody [HL1033]

Catalogue Number: GTX635873-GTX

Molecular Weight:27
Physical state:Liquid
Type:Monoclonal Primary Antibody - Unconjugated
Alias:myelin basic protein , C76307 , Hmbpr , R75289 , golli-mbp , jve , mld , shi
Shipping Condition:Blue Ice
Unit(s): 100 ul, 25 ul
Host name: Rabbit
Clone: HL1033
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse Myelin basic Protein. The exact sequence is proprietary.
Application: ICC, IF, IHC-P, WB


Description: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the shiverer and myelin deficient phenotypes in mouse. [provided by RefSeq, Jul 2008]

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1 mg/ml

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For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

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Gene Alias

myelin basic protein , C76307 , Hmbpr , R75289 , golli-mbp , jve , mld , shi


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