DUT antibody [HL1210]

Catalogue Number: GTX636527-GTX

Manufacturer:	GeneTex
Preservative:	No Preservative
Physical state:	Liquid
Type:	Recombinant Monoclonal
Alias:	deoxyuridine triphosphatase , dUTPase
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:	HL1210
Isotype:	IgG
Immunogen:	Recombinant protein encompassing a sequence within the center region of human DUT. The exact sequence is proprietary.
Application:	ICC, IF, IHC-P, WB

Overview
Datasheets

Description

Description: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

DUT

Uniprot ID

P33316

Concentration

1 mg/ml

Gene ID

1854

Purification

Protein A purified

Antibody Clonality

Recombinant Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Application Notes

IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX636527 Datasheet

Price

£285.00

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Quantity
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