p53 antibody [HL2697]
Catalogue Number: GTX639448-GTX
GTX639448 Image
GTX639448 Image
p53 antibody [HL2697] detects p53 protein on whole mount zebrafish by immunohistochemical analysis. Sample: Paraformaldehyde-fixed 1 day-post-fertilization zebrafish embryo. Green: p53 stained by p53 antibody [HL2697] (GTX639448) diluted at 1:100. Antigen Retrieval: Tris-HCl buffer, pH 9.0, 20 min at 70oC
| Manufacturer: | GeneTex |
| Preservative: | No preservative |
| Molecular Weight: | 42 |
| Physical state: | Liquid |
| Type: | Recombinant Monoclonal |
| Alias: | tumor protein p53 , brp53 , drp53 , etID22686.5 , fb40d06 , p53 , wu:fb40d06 , zgc:111919 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | HL2697 |
| Isotype: | IgG |
| Immunogen: | Recombinant fragment of zebrafish p53. |
| Application: | IHC-WM |
Description
Description: Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification and transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). [provided by Alliance of Genome Resources, Apr 2022]
Additional Text
Gene Name
TP53
Gene ID
30590
Purification
Protein A purified
Uniprot ID
P79734
Antibody Clonality
Recombinant Monoclonal
Concentration
1 mg/ml
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX639448 Datasheet
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