Mouse CTLA4 protein, mutant mouse IgG2a Fc tag (active)

Catalogue Number: GTX65784-PRO-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Physical state:	Lyophilized
Type:	Immune Checkpoint Proteins
Alias:	cytotoxic T-lymphocyte-associated protein 4 , Cd152 , Ctla-4 , Ly-56
Host Cell:	NS-1 Cells
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Application:	FA

Overview
Datasheets

Additional Text

Gene ID

12477

Gene Name

CTLA4

Protein Tag

mMutIgG2a Fc Tag

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Application Notes

Blocks the binding of mouse CD80 (B7-1) and CD86 (B7-2) to their receptors (by binding CD80 and CD86 with high affinity) and thereby prevents their T cell regulatory actions by inhibiting the CD28 signaling competitively. Shows the biological functions of the CD152 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Useful for investigating the T cell co-stimulation.

Short Description

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Storage Note

Store at -20C or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

GTX65784-PRO Datasheet

Price

£202.00

-

Quantity
Unit Size

Find out about delivery