Human Growth hormone Receptor protein, His tag (active)

Catalogue Number: GTX67031-PRO-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Physical state:	Liquid
Type:	Bioactive Proteins
Alias:	growth hormone receptor , GHBP , GHIP
Host Cell:	Baculovirus
Shipping Condition:	Dry Ice
Unit(s):	50 ug
Application:	FA

Overview
Datasheets

Description

Description: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Additional Text

Gene Name

GHR

Gene ID

2690

Uniprot ID

P10912

Protein Tag

HIS Tag

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Concentration

1 mg/ml

Application Notes

Measured by ability to inhibit GH-induced proliferation assay using Nb2-11 Rat lymphoma cells in the presence of 1.25 ng/ml of human growth hormone. The ED₅₀ for this effect is equal to or less than 10 ng/ml.

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX67031-PRO Datasheet

Price

£292.00

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Quantity
Unit Size

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