Human TNF alpha protein, His tag (active)
Catalogue Number: GTX67165-PRO-GTX
| Manufacturer: | GeneTex |
| Preservative: | no preservative|No preservative |
| Physical state: | Liquid |
| Type: | Cytokines |
| Alias: | tumor necrosis factor , DIF , TNF-alpha , TNFA , TNFSF2 , TNLG1F |
| Host Cell: | Baculovirus |
| Shipping Condition: | Dry Ice |
| Unit(s): | 50 ug |
| Application: | FA |
Description
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
TNF
Gene ID
7124
Uniprot ID
P01375
Protein Tag
HIS Tag
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Concentration
1 mg/ml
Application Notes
Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED₅₀ for this effect is less or equal to 0.2 ng/ml.
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX67165-PRO Datasheet
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