ATM antibody [2C1]
Catalogue Number: GTX70103-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | ChIP Validated Antibodies |
| Alias: | ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2C1 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056. |
| Application: | ELISA, FACS, ICC, IF, IHC-P, IP, ChIP, WB, IHC |
Description
Description: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Additional Text
Gene Name
ATM
Concentration
1 mg/ml
Gene ID
472
Uniprot ID
Q13315
Purification
Affinity Purified
Molecular Weight
351
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
Recommended Starting Dilutions:For WB: Use at a dilution of 1:500-1:3000. Predicted 350 kDa. For IHC-P: Use at 5 µg/mL. Antigen retrieval in Citrate buffer is recommended.For IP: Use at a concentration of 1-10 µg/ml. For ICC/IF: Please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. For FACS:Use at an dependent assay. Optimal dilutions/concentrations should be determined by the researcher.
Short Description
ATM antibody [2C1] is a mouse monoclonal antibody developed by Dr. Eva Lee's lab at the University of Texas Health Science Center at San Antonio (PMID: 8969240). It is a well-validated and highly cited reagent to detect ATM protein, which is a nuclear serine/threonine kinase that plays a pivotal role in DNA damage sensing and repair.
GTX70103 Datasheet
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