BRCA1 antibody [6B4] - ChIP grade

Catalogue Number: GTX70115-GTX

Manufacturer:	GeneTex
Preservative:	No Preservative
Physical state:	Liquid
Type:	ChIP Validated Antibodies
Alias:	BRCA1 DNA repair associated , BRCAI , BRCC1 , BROVCA1 , FANCS , IRIS , PNCA4 , PPP1R53 , PSCP , RNF53
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	6B4
Isotype:	IgG1
Immunogen:	BRCA1 protein fragment expressed in E. coli corresponding to amino acids 341-748.
Application:	ICC, IF, IHC-P, IP, ChIP, WB, IHC

Overview
Datasheets

Description

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]

Additional Text

Gene ID

672

Gene Name

BRCA1

Uniprot ID

P38398

Purification

Protein G purified

Molecular Weight

208

Concentration

2.75 mg/ml

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX70115 Datasheet

GTX70115 Reference

Price

£285.00

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