FEN1 antibody [4E7]

Catalogue Number: GTX70185-GTX

Manufacturer:	GeneTex
Preservative:	No Preservative
Physical state:	Liquid
Type:	ChIP Validated Antibodies
Alias:	flap structure-specific endonuclease 1 , FEN-1 , MF1 , RAD2
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:
Isotype:	IgG1
Immunogen:	Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.
Application:	ICC, IF, IP, ChIP, WB

Overview
Datasheets

Description

Description: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

FEN1

Gene ID

2237

Uniprot ID

P39748

Purification

Protein G purified

Concentration

1.73 mg/mL

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Application Notes

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX70185 Datasheet

GTX70185 Reference

Price

£285.00

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Quantity
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