p53 antibody [DO1]

Catalogue Number: GTX70214-GTX

Manufacturer:GeneTex
Molecular Weight:44
Physical state:Liquid
Type:Monoclonal Primary Antibody - Unconjugated
Alias:Tumor Protein P53 , Bcc7 , Lfs1 , P53 , Trp53 , Tp53
Shipping Condition:Dry Ice
Unit(s): 200 ul, 10 ul
Host name: Mouse
Clone: DO1
Isotype: IgG2a
Immunogen: Recombinant human p53 expressed in E. coli.
Application: ELISA, FACS, ICC, IF, IHC-P, IP, WB, IHC-Fr

Description

Description: The p53 antibody, clone DO1, specifically recognizes an epitope at the N-terminal end of the human p53 protein between amino acids 20-25. p53 is a tumor suppressor gene that is mutated in a wide variety of sporadic and familial cancers. And p53, as a nuclear protein, mediates cell cycle arrest in response to DNA damage and therefore is important in the maintenance of genomic stability. Recent results indicate an enhanced phosphorylation of p53 by ATM in response to DNA damage on SER15, a mutation which reduces the ability of p53 to arrest cell growth.

Additional Text

Gene Name

TP53

Concentration

1 mg/ml

Gene ID

7157

Uniprot ID

P04637

Molecular Weight

44

Price
236.00


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