Catalogue Number: GTX70214-GTX
|Type:||Monoclonal Primary Antibody - Unconjugated|
|Alias:||Tumor Protein P53 , Bcc7 , Lfs1 , P53 , Trp53 , Tp53|
|Shipping Condition:||Dry Ice|
|Unit(s):||200 ul, 10 ul|
|Immunogen:||Recombinant human p53 expressed in E. coli.|
|Application:||ELISA, FACS, ICC, IF, IHC-P, IP, WB, IHC-Fr|
Description: The p53 antibody, clone DO1, specifically recognizes an epitope at the N-terminal end of the human p53 protein between amino acids 20-25. p53 is a tumor suppressor gene that is mutated in a wide variety of sporadic and familial cancers. And p53, as a nuclear protein, mediates cell cycle arrest in response to DNA damage and therefore is important in the maintenance of genomic stability. Recent results indicate an enhanced phosphorylation of p53 by ATM in response to DNA damage on SER15, a mutation which reduces the ability of p53 to arrest cell growth.