TSG101 antibody [4A10]
Catalogue Number: GTX70255-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | Recombinant Monoclonal |
| Alias: | tumor susceptibility 101 , TSG10 , VPS23 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4A10 |
| Isotype: | IgG1 |
| Immunogen: | Amino acids 167-374 of TSG101 protein expressed in E. coli. |
| Application: | ELISA, FACS, ICC, IF, IHC-P, IP, EM, WB, IHC, IHC-Flt |
Description
Description: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
TSG101
Uniprot ID
Q99816
Gene ID
7251
Concentration
1.8 mg/mL
Purification
Affinity Purified
Molecular Weight
44
Antibody Clonality
Recombinant Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:3000. ICC/IF: 1:500-1:1000. IHC-P: 1:100-1:1000. FACS: 1:25-1:200. EM: 1:10. IHC: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
TSG101 antibody [4A10] is a well-validated and highly cited mouse monoclonal antibody that detects TSG101, a protein of 390 amino acids and a predicted molecular weight of 44 kDa that is a core constituent of the ESCRT-I complex. Reports have described it having both tumor suppressor and tumor enhancer activities. TSG101 is involved in exosome secretion and is commonly used as an exosome marker.
GTX70255 Datasheet
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