HLA-B27 antibody [HLA-ABC-m3] (FITC)
Catalogue Number: GTX74708-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.1% Sodium azide |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | major histocompatibility complex, class I, B , AS , B-4901 , HLAB |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ul |
| Host name: | Mouse |
| Clone: | HLA-ABC-m3 |
| Isotype: | IgG2a |
| Immunogen: | Immune complex precipitated from HLA-B27 positive cell line (Bordin) by anti HLA-antibody and Staphylococcal Protein A. |
| Application: | FC |
Description
Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Additional Text
Gene Name
HLA-B
Concentration
50 ug/ml
Gene ID
3106
Purification
Ion Exchange
Uniprot ID
P01889, P03989
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.
Application Notes
FCM: Neat. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX74708 Datasheet
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