CD16 antibody [LNK16] (FITC)

Catalogue Number: GTX74719-GTX

Manufacturer:GeneTex
Preservative:15 mM Sodium azide
Molecular Weight:29
Physical state:Liquid
Type:Monoclonal Primary Antibody - Conjugated
Alias:CD16 , CD16A , FCG3 , FCGR3 , FCGR3A , FCGRIII , FCR10 , FCRIII , FCRIIIA , Fc fragment of IgG receptor IIIa , IGFR3 , IMD20 , CD16a
Shipping Condition:Blue Ice
Unit(s): 100 tests
Host name: Mouse
Clone: LNK16
Isotype: IgG1
Immunogen: Normal human peripheral blood granulocytes
Application: FC

Description

Description: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Additional Text

Gene ID

2214

Gene Name

FCGR3A

Uniprot ID

P08637

Antibody Clonality

Monoclonal

Purification

Size-exclusion Chromatography

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

Application Notes

FCM: 20 µl reagent / 100 µl of whole blood or 10⁶ cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.