Fas antibody [LOB 3/17] (FITC)

Catalogue Number: GTX75107-GTX

Manufacturer:	GeneTex
Preservative:	0.09% sodium azide
Molecular Weight:	38
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Fas cell surface death receptor , ALPS1A , APO-1 , APT1 , CD95 , FAS1 , FASTM , TNFRSF6
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	LOB 3/17
Isotype:	IgG1
Immunogen:	Fusion protein comprising extracellular domain of human Fas linked to human Fc.
Application:	FC

Overview
Datasheets

Description

Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Additional Text

Gene Name

FAS

Gene ID

355

Uniprot ID

P25445

Concentration

0.1 mg/ml

Purification

Protein A purified

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles. Protect from light.

Application Notes

FCM: Neat-1/10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX75107 Datasheet

Price

£410.00

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