TCR V alpha 2 antibody [F1] (FITC)

Catalogue Number: GTX79225-GTX

Manufacturer:	GeneTex
Preservative:	0.1% Sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	T cell receptor alpha variable 2 , TCRAV11S1 , TCRAV2S1
Shipping Condition:	Blue Ice
Unit(s):	200 tests
Host name:	Mouse
Clone:	F1
Isotype:	IgG2a
Immunogen:	Human TCR V alpha-2
Application:	FC, WB, IHC

Overview
Datasheets

Description

Description: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

Additional Text

Concentration

0.15 mg/ml

Gene ID

28691

Purification

Protein A purified

Gene Name

TRAV2

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. Protect from light.

Application Notes

FCM: 1-2 µg/test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX79225 Datasheet

Price

£410.00

-

Quantity
Unit Size

Find out about delivery