TCR V beta 12 antibody [S511]

Catalogue Number: GTX79235-GTX

Manufacturer:	GeneTex
Preservative:	0.1% Sodium azide
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	T cell receptor beta variable 12-5 , TCRBV12S5 , TCRBV8S3 , TRBV125
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Mouse
Clone:	S511
Isotype:	IgG2b
Immunogen:	Human TCR V beta 12
Application:	FC, ICC, IF, IP, IHC-Fr, IHC, Act

Overview
Datasheets

Description

Description: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq]

Additional Text

Concentration

0.12 mg/ml

Gene ID

28575

Purification

Protein A purified

Gene Name

TRBV12-5

Antibody Clonality

Monoclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Application Notes

FCM: 1-2 µg/test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX79235 Datasheet

Price

£410.00

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