Factor XII antibody

Catalogue Number: GTX79764-GTX

Manufacturer:	GeneTex
Preservative:	no preservative\|No preservative
Molecular Weight:	68
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	F12,HAE3,HAEX,HAF,coagulation factor XII,FA12,Factor XII
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Sheep
Clone:
Isotype:	IgG
Immunogen:	Full length native protein (purified) (Human).
Application:	ELISA, WB

Overview
Datasheets

Description

Description: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

Additional Text

Concentration

10 mg/mL

Gene Name

F12

Gene ID

2161

Uniprot ID

P00748

Purification

Protein G purified

Molecular Weight

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

GTX79764 Datasheet

Price

£386.00

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