HLA-DR1 antibody [MEM-267] (PE)

Catalogue Number: GTX79956-GTX

Manufacturer:	GeneTex
Preservative:	15 mM Sodium azide
Molecular Weight:	30
Physical state:	Liquid
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	DRB1 , HLADR1B , HLADRB , HLADRB1 , SS1 , major histocompatibility complex, class II, DR beta 1 , HLA Class II DRB1 , HLA-DRB1 , MHC Class II DRB1
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	MEM-267
Isotype:	IgG2b
Immunogen:	Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
Application:	FC, WB

Overview
Datasheets

Description

Description: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Additional Text

Gene Name

HLA-DRB1

Gene ID

3123

Concentration

0.1 mg/ml

Uniprot ID

P01911, P01912, P13761, Q29974

Antibody Clonality

Monoclonal

Purification

Size-exclusion Chromatography

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Storage Note

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4C. DO NOT FREEZE. Protect from light.

GTX79956 Datasheet

GTX79956 Reference

Price

£386.00

-

Quantity
Unit Size

Find out about delivery